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Ciudad Obregón, city, northwestern Mexico, in Sonora State, in an irrigated lowland of the Yaqui River in the Llanos de Sonora. A rail and road transportation hub, it is the center of an agricultural area producing rice, cotton, corn, fruit, vegetables, and livestock. Fruit canning and rice and flour milling are the major manufacturing industries of the city; copper is mined nearby.

The city was formerly called Cajeme (now the name of a village west of the city) but was renamed in honor of Álvaro Obregón, soldier and president of Mexico in the 1920s, who was born in this part of the state. Population (1995) 345,222.